Spray a 5 1/2- to 6-quart slow cooker generously with cooking spray.
In a large bowl, beat cake mix, pumpkin, water, vegetable oil, eggs, and pumpkin pie spice with an electric mixer on low speed for 1 minute, scraping the bowl constantly. Increase speed to medium and beat for 2 minutes. Alternatively, mix by hand with a whisk.
Pour batter into the slow cooker; cover and cook on HIGH for 1 hour 45 minutes or until a toothpick inserted into the center comes out clean.
Uncover and cool for 10 minutes with slow cooker off. Run a knife around the edge to loosen the cake; turn out onto a cooling rack and cool completely.
In a medium bowl, beat cream cheese, butter, and vanilla with an electric mixer on low speed until smooth.
Gradually add confectioners sugar, about 1 cup at a time, beating on low speed until smooth and spreadable.
Spread the cream cheese frosting over the cooled cake evenly.
Cut the cake into pieces and serve.
Notes
This pumpkin cake is ideal for fall gatherings, with a tender crumb and a rich, creamy frosting that everyone will love.