Preheat oven to 375°F (190°C). Grease a loaf pan or line a baking sheet with parchment paper.
In a large bowl, combine the ground chicken, bread crumbs, chopped onion, milk, eggs, salt, pepper, and Worcestershire sauce. Mix gently until just combined. Do not overmix.
Press the mixture evenly into the prepared loaf pan or shape it into a loaf on the baking sheet.
In a small bowl, whisk together the ketchup, brown sugar, and Dijon mustard for the glaze. Spread evenly over the top of the meatloaf.
Bake for 50-60 minutes, or until the internal temperature reaches 165°F (74°C) and the glaze is bubbly.
Let the meatloaf rest for 10 minutes before slicing and serving.
Notes
Serve with your favorite sides like mashed potatoes or roasted vegetables.